PT-141 (Bremelanotine) 10mg

PT-141 (chemically known as Bremelanotine) is a synthetic cyclic heptapeptide analog of $\alpha$-melanocyte-stimulating hormone ($\alpha$-MSH) and a derivative of Melanotan II. It is a first-in-class, centrally acting Melanocortin Receptor Agonist approved for the treatment of generalized Hypoactive Sexual Desire Disorder (HSDD) in premenopausal women and widely studied in men for erectile dysfunction.

Unlike traditional vascular treatments (such as PDE5 inhibitors like sildenafil or tadalafil) that work peripherally on smooth muscle blood vessels, PT-141 acts directly on the central nervous system to activate neural pathways that regulate sexual desire, motivation, and arousal. The 10mg vial provides a multi-dose lyophilized formulation for ongoing research protocols.

Key Benefits & Applications

• Central Nervous System Arousal: Directly stimulates hypothalamic brain regions to initiate authentic sexual desire and psychological motivation in both men and women.

• Effective in Non-Vascular ED: Works independently of the vascular pathway, making it effective for erectile dysfunction unresponsive to standard PDE5 inhibitors or driven by neurogenic/psychogenic factors.

• HSDD Management: Increases sexual desire, reduces distress related to low desire, and enhances subjective arousal in premenopausal women.

• No Vasodilation-Driven Drop in BP: Does not cause systemic vasodilation-related nitrate interactions associated with traditional ED drugs.

• On-Demand Efficacy: Exhibits a predictable onset time, remaining active in central pathways for up to 8 to 12 hours.